Old poster here...looking for help on lining issues

Holly
Holly

5:04 PM - Mar 07, 2018 #1

Good Morning Ladies!

I haven't posted here in a couple years. Thru LIFE IVF I banked 8 blasts and one Day 2 (between the ages of 40-42). Since that time we've transferred 4 out of the 8 blasts (1 chemical) with SEVERAL cancelled cycles due to lining. My lining thickness hasn't necessarily been the issue as of late (generally around 9/10mm). My quality/pattern for whatever reason is creating huge obstacles. I can't seem to achieve tri-laminar/multi layered. Most of my scans in recent months have all been homogeneous. I'm using Vivelle patches with a protocol of 1 patch every other day starting on CD 3 and then upping the dose to 2 patches every other day on CD 7. Everything I've read seems to imply linings typically start out as tri-laminar due to the estrogen levels increasing. With exposure to P4 they then convert to homogeneous (generally after ovulation). My P4 generally hasn't gone above 0.8 during the first half of my cycle.

I'm 45 now and definitely on the downhill slope in terms of fertility. I'd rather not go down the road of a surrogate. I also don't necessarily want to transfer the precious embies we have left into a less than ideal situation. Dr. Yelian will transfer 1 embie at time into a less than perfect scenario. Not sure how I feel about that course of action.

I've had a lap in the last 18 months to rule out fibroids or any adhesions in my uterus. I think it's just a function of getting old unfortunately. Not sure if there's a specialist out there (seems like there was one located in the Midwest that focused on auto immune issues) that I should contemplate seeing?? Kind of done at this point but still want to give it the good ole' college try.

Sighh...any advice would be very appreciate. BTW, taking everything under the moon including raspberry leaf, L-arginine, vitamin E, castor oil packs and all the rest.

Thanks and God Bless!

Holly
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Anonymous
Anonymous

6:04 PM - Mar 07, 2018 #2

Just for info..a clinic in Lubbock has their own pool of Gestational Carriers so lower cost than an Agency. I hope you do not need them.
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Joined: 6:19 PM - Jun 10, 2014

9:40 PM - Mar 07, 2018 #3

Good Morning Ladies!

I haven't posted here in a couple years. Thru LIFE IVF I banked 8 blasts and one Day 2 (between the ages of 40-42). Since that time we've transferred 4 out of the 8 blasts (1 chemical) with SEVERAL cancelled cycles due to lining. My lining thickness hasn't necessarily been the issue as of late (generally around 9/10mm). My quality/pattern for whatever reason is creating huge obstacles. I can't seem to achieve tri-laminar/multi layered. Most of my scans in recent months have all been homogeneous. I'm using Vivelle patches with a protocol of 1 patch every other day starting on CD 3 and then upping the dose to 2 patches every other day on CD 7. Everything I've read seems to imply linings typically start out as tri-laminar due to the estrogen levels increasing. With exposure to P4 they then convert to homogeneous (generally after ovulation). My P4 generally hasn't gone above 0.8 during the first half of my cycle.

I'm 45 now and definitely on the downhill slope in terms of fertility. I'd rather not go down the road of a surrogate. I also don't necessarily want to transfer the precious embies we have left into a less than ideal situation. Dr. Yelian will transfer 1 embie at time into a less than perfect scenario. Not sure how I feel about that course of action.

I've had a lap in the last 18 months to rule out fibroids or any adhesions in my uterus. I think it's just a function of getting old unfortunately. Not sure if there's a specialist out there (seems like there was one located in the Midwest that focused on auto immune issues) that I should contemplate seeing?? Kind of done at this point but still want to give it the good ole' college try.

Sighh...any advice would be very appreciate. BTW, taking everything under the moon including raspberry leaf, L-arginine, vitamin E, castor oil packs and all the rest.

Thanks and God Bless!

Holly
Dear Holly,

I have been stuck myself for several years due to lining issues, but in my case, the problem is the thickness, no problems with the trilaminar pattern.

Have you ruled out any infection, or tubal leakage? A hysteroscopy would be a must also. From my research and the suggestions from my current local RE, I think it would also be worthwhile performing an ERA (endometrial receptivity array) test. However, I think infections should be ruled out first, s.t. you don't waste money on the ERA test.

I haven't researched homogeneous lining in particular, just general lining issues, since my problem is the thickness. What I can tell is that the form of estradiol seems to make a difference for me. This cycle I took for the first time Estrofem (estrace-equivalent, I am in Europe) and lenzetto transdermal spray, a high dose also, versus progynova/climara before. My lining got for the first time over 6mm from estradiol only (I also achieved over 6 mm on tamoxifen, but I am afraid of its side-effects, and I don't know if it actually affects receptivity).

I kept taking the l-arginine/viagra/aspirin/raspberry leaf/vitamin E/maca/acupuncture etc in the past - I don't think it made any difference.

I noticed recent news of new treatment for lining thickness from New Hope - it seems Dr. Mehri is the doctor who is most experienced with lining at NH. Might be worth having a consult with him.

Until now, my major frustration came from handling everything remotely, which made it very hard to schedule procedures, and try alternative medication available locally. It was not that much an issue of having a consult to identify the cause of the thin lining. (Well, last year I was told that it could be caused by a subserous fibroid, I had it removed, but I don't think this was the cause.) But in your case, it seems to me that the cause should be diagnosed.

Sorry I cannot help more... But I am with you, and fully understand everything this means... Wish you lots of luck, and hang in there.
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Michelle
Michelle

8:16 AM - May 13, 2018 #4

Holly, I got pregnant and had a successful outcome at Life IVF on my first transfer at 42. Now I'm trying for a second baby at age 44. I personally think at this age it's my last shot too. And, I am giving it my all because I have 4 embryos left and might as well go for it. 

I don't know if you have a child already, so I am sorry if this sounds insensitive, but I think at our age I would give the surrogate a shot. I don't have lining issues that I know of, but if I did run into complications I would probably just throw in the towel or if I could afford it, hire a surrogate. 

If your lining issues are the only thing standing between you and potentially having your own child, why go through the hassle of more doctors and medical appointments that may or may not fix your issue and result in you having to wait another 6 months or even years to potentially fix this issue, but potentially not as well? 

If you can afford it, I would hire a surrogate. In my opinion, being pregnant at this age was awful and it is the scariest part for me trying again. I worry about the toll on my health and body because it was hard at age 42 and now I know it would be even worse at age 44.

I know some women want to experience what being pregnant is like, but to me, it wasn't that great and I didn't feel that bonded to my baby in my womb until he was born anyway. And my biggest regret was not trying to have a baby sooner, because HOW it happens is less important than WHEN it happens, in my opinion. 

Sorry if this is too blunt or honest, but I just wanted to share that so you can really consider whether it makes sense to keep waiting for the optimal lining conditions or to just try to have a baby as soon as you can. 
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