found this in a paper I was reading about IVF and PGD
Basically, based on studies in animals, more chromosomally abnormal (aneuploid) embryos are found when doing IVF than in in the natural setting (suggesting IVF somehow causes embryos to become aneuploid). For ethical reasons they can't test in humans obviously but it certainly may explain why older women have better luck naturally
here is the discussion from the paper:
Not all morphologically normal IVF embryos are also chromosomally normal. Although day 3 embryo morphology has been recently shown to be a selection marker of euploidy among advancedmaternal age subjects, it had a poor predictive value for euploidy in younger women who may have other factors responsible for embryo dysmorphism (4). Indeed, a high rate of aneuploidy and mosaicism is revealed even when only top-quality IVF embryos are analyzed by FISH. For obvious ethical reasons, comparative studies on chromosome abnormalities in in vivoderived and in vitroproduced human embryos are not available. Studies on other mammalian species (mouse, cow, sheep), however, have demonstrated a higher rate of aneuploidy in IVF embryos compared with their in vivo counterparts (29). Collectively, these data indicate that human IVF embryos probably have a higher degree of aneuploidy compared with the naturally developed embryos which are not accessible for research
If the meds, injectables vs Clomid, or what dose of injectables?
Do you have the link of the original paper? Thanks!