Saving People, Hunting Things. The Family Business
The Winchester family has a long history as Men of Letters. However, after the disappearance of Henry Winchester in 1958, that tradition was lost. His son, John, was not brought up with the legacy of the supernatural, but was thrust into it after the death of his wife, Mary (ni Campbell) at the hands of a yellow-eyed demon. He raised his sons, Dean and Sam, to be hunters. John later traded his own life to that demon in exchange for his son's. He had another son, Adam Milligan, who was not raised as a hunter, but was nonetheless pulled into it when first ghouls, then angels sought to use him to get to the Winchesters.
Dean and Sam have had infamous careers as hunters, and are well known in the hunting community. Not always positively. Sam accidentally started the Apocalypse and was on a few shit lists until he sacrificed himself to end it. When that happened, Dean gave up hunting and looked for "a normal life" with a woman named Lisa Braedan. Though that relationship ended when Dean returned to hunting, Dean had grown close to Lisa's son, Ben, and still acts as a father figure to him.
Henry and Millie Winchester
--John and Mary (Campbell) Winchester
------Benjamin "Ben" Braedan, foster son
----Samuel "Sam" Winchester
Campbell, Braedan, Milligan.