my poor lovely friend just had second DE fail

my poor lovely friend just had second DE fail

Joined: June 2nd, 2007, 7:45 am

March 21st, 2012, 3:16 am #1

she has been travelling to South Africa to do this cos donors are so hard to find here in New Zealand..
I'm suggesting immune tx(she has tested negative for everything), and further sperm testing...karyotyping and fragmentation is it?
She's determined to keep trying but has had a hell of a year...also lost her house in the quakes...
She has transferred five good quality DE blasts as well as her own two OE IVFs...
Any other suggestions?
Last edited by phoebegrace on March 21st, 2012, 3:18 am, edited 1 time in total.
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Ariadne
Ariadne

March 21st, 2012, 3:25 am #2

How hard. I remember how devastating the failed DE cycles were.

I stared with karyotyping & sperm dna fragmentation. When those were normal & excellent, respectively, I then turned to immune testing, which I did not expect to be an issue initially.

I would start with the easiest & cheapest, & often overlooked, first, which is further issues with the sperm.

I hope she finds success in the future. It's so hard but so worth it, as you know.
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Bluesky
Bluesky

March 21st, 2012, 3:32 am #3

she has been travelling to South Africa to do this cos donors are so hard to find here in New Zealand..
I'm suggesting immune tx(she has tested negative for everything), and further sperm testing...karyotyping and fragmentation is it?
She's determined to keep trying but has had a hell of a year...also lost her house in the quakes...
She has transferred five good quality DE blasts as well as her own two OE IVFs...
Any other suggestions?
I am very sorry to hear about your friend. I am not sure if this is an option, but your friend's situation made me think of a friend from another board who is from AUS. she had 2 failed DE cycles here in the U.S. for her 3rd cycle she consulted with her FS in Australia about a natural FET protocol for the frozens she had left over from Donor 2. Her US clinic used the recommended protocol (will ask her if you are interested). She just had her twins last week. She will probably never know what caused this cycle go work vs. the others, but the thinking of "less drugs" seemed to resonate and work for her..
Immune/Karyotyping testing is a good suggestion
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Ariadne
Ariadne

March 21st, 2012, 3:41 am #4

In addition to everything else I dealt with, immune-wise, my 2 successes were on natural FETs. I, too, feel my body did much better on natural FETs, although immune issues were still an issue.
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futurebeauty
futurebeauty

March 21st, 2012, 3:47 am #5

she has been travelling to South Africa to do this cos donors are so hard to find here in New Zealand..
I'm suggesting immune tx(she has tested negative for everything), and further sperm testing...karyotyping and fragmentation is it?
She's determined to keep trying but has had a hell of a year...also lost her house in the quakes...
She has transferred five good quality DE blasts as well as her own two OE IVFs...
Any other suggestions?
I am in the thick of info gathering about immune issues myself. I would go for sperm and karytyping for DH. I would suggess all the immune testing that have come up recently about my posts. I will try and write more later as I am so tired and been on the internet too long tonight.

I hope your friend heals well and continues to strive for her dream.

FB
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minniet
minniet

March 21st, 2012, 4:20 am #6

she has been travelling to South Africa to do this cos donors are so hard to find here in New Zealand..
I'm suggesting immune tx(she has tested negative for everything), and further sperm testing...karyotyping and fragmentation is it?
She's determined to keep trying but has had a hell of a year...also lost her house in the quakes...
She has transferred five good quality DE blasts as well as her own two OE IVFs...
Any other suggestions?
I agree about sperm checking (it's cheap), but also the right lab drawing the bloodwork? Maybe a long distance Beer consult?

What was her protocol? Maybe adding dex and heparin -- can she get intralipids? They seem to help for some mysterious reason and do no harm...

Sorry about this, so hard.
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Joined: June 2nd, 2007, 7:45 am

March 21st, 2012, 4:34 am #7

Sounds like I'm on the right suggestion track. She has no frozens left so starting anew but will suggest natural FET as well. It's just so bloody unfair. As we all know....
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Joined: December 10th, 2008, 6:33 pm

March 21st, 2012, 5:09 am #8

she has been travelling to South Africa to do this cos donors are so hard to find here in New Zealand..
I'm suggesting immune tx(she has tested negative for everything), and further sperm testing...karyotyping and fragmentation is it?
She's determined to keep trying but has had a hell of a year...also lost her house in the quakes...
She has transferred five good quality DE blasts as well as her own two OE IVFs...
Any other suggestions?
is South Africa the best way to go for you regarding where you are located?
I went to SDFC that's in California, and though it is far, I had a proven donor and have lots of frozens.
I remember they work alot with out of town, even had someone from Australia there when I was there.

I am just wondering, due to the high stats and usually but of course no guarantee of frozens, would it be more cost effective for her to go to a clinic that is like SDFC?
Is South Africa Clinic solid in it's Fresh and frozen stats?

I am so sorry I have a dear friend who is also going through a lot of pain with a failed DE cycle.
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Joined: June 2nd, 2007, 7:45 am

March 21st, 2012, 6:26 am #9

for us....like double or triple the amount and time it takes...we are a loooong way from anywhere down here. LOL....
And the clinic is pretty good from what I understand.
thanks anyway.
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Joined: June 2nd, 2007, 7:45 am

March 21st, 2012, 6:28 am #10

How hard. I remember how devastating the failed DE cycles were.

I stared with karyotyping & sperm dna fragmentation. When those were normal & excellent, respectively, I then turned to immune testing, which I did not expect to be an issue initially.

I would start with the easiest & cheapest, & often overlooked, first, which is further issues with the sperm.

I hope she finds success in the future. It's so hard but so worth it, as you know.
will pass that on. She's determined to keep trying just yet....
It's bittersweet for me to be the one who has finally found success and to have a friend struggling so hard; I've been in that other role for so many years its far more familiar to me than the support one...
But she's so worth it...as is the end result, hopefully..
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