Immune problems

Immune problems

Anonymous
Anonymous

January 6th, 2012, 9:03 pm #1

Is there anyone out there with a positive ANA that has had success without any type of special treatment?
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thesameboat
thesameboat

January 6th, 2012, 9:52 pm #2

I'll tell you what I took. I tested positive for ANAs after 6 negative cycles. Then I took:

15 mg prednisone, 5 mg folic acid, B6 and B12 (though those were for the MTHFR), antibiotics for 3 days before transfer and 3 days post transfer (though that was for the chlamydia they suspected was high in my uterus ... all tests were always negative but I had antibodies in my blood), daily shots of fragmin (a kind of heparin), fish oil, and, after the next cycle resulted in a m/c, over-the-counter bovine colustrum and 2 injections of Granocyte (one 2 hours before transfer and one 24 hours later). This was all on the advice of a reproductive immunologist.

(Note: I'm not in the US, so some things might be different.)

Best of luck to you.
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Daisy
Daisy

January 6th, 2012, 10:08 pm #3

Is there anyone out there with a positive ANA that has had success without any type of special treatment?
The ANA titre may be high as a result of autoimmune issues which left untreated may prevent implantation or cause miscarriage.

It depends also what your fertility and medical history are? How many attempt at ivf/DE ivf have you have? What medical issues do you have?

Have you ever been tested for issues which prevent pregnancy? These would basically be:-

Uterine testing (hysteroscopy)
Clotting (inc. MTHFR, FVL and other thrombophilias)
Autoimmune - Most important is thyroid, Rhematoid factor, ANAs, Antiphospholipid Syndrome etc.
Sperm issues
Infection for you and DH (Ureaplasma, Mycoplasma, chlamydia etc)
Karyotype for your DH to check for any genetic issues.

You do need some specialist advice on the impact of high ANAs in your specific case.

Treatment for ANAs usually includes Prednisone taken from start of cycle until 12 weeks of pg. Sometimes also Lovenox prescribed as some immune reactions increase chance of placental clotting.

Possibly aspirin but needs Docs. advice.

You need to get further testing and advice from an RI if possible.

Best of luck,

Daisy
xxx
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Daisy
Daisy

January 6th, 2012, 10:09 pm #4

Sorry can't edit - pg and m/c all mentioned in above post. x
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Joined: January 19th, 2007, 7:18 pm

January 8th, 2012, 5:06 am #5

Is there anyone out there with a positive ANA that has had success without any type of special treatment?
There is a range of immune issues and treatments.

Certainly there are women who have succeeded with dx. immune issues & no treatment; women who didn't succeed until very expensive, comprehensive treatment (me, unfortunately); & those in the middle, who succeeded with minimal or moderate intervention (steroids, anticoagulants, for example).

To say sorting out who needs what in advance is very difficult is an understatement, unfortunately. And b/c it can be very difficult & expensive to deal with the more comprehensive tests & treatment, this is no small obstacle.

For me, elevated ANA, speckled pattern was actually the first sign something was amiss, but I was a difficult case & most certainly, not everyone with elevated ANA is like me or will need to do what I needed to do.
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