@ DeeinNYC...Immune ?

@ DeeinNYC...Immune ?

Violet
Violet

July 19th, 2012, 1:43 am #1

Hi Dee,
I hope you are doing well. I have been following you and cheering you on for some time now. I so hope you get your bfp soon.

I read some old posts where you talked about neupogen. I recently had an appt. with Dr. B and he recommended neupogen due to a high # of HLA matches as well as intralipids due to elevated NK cells. The rest of the immune panel was negative.

I read that you did not do HLA matching because you would not treat it with neupogen. From my understanding of your post, you mentioned something about transferring one embryo and then you lost me. So, would the immune reaction not be as strong with one embryo transferred? Are there other recommendations instead of neupogen? It is pricey if our insurance does not cover it. I am looking into that tomorrow.

Also, if I recall correctly, you have done intralipds and you have had them administered in your Dr's office, correct? I will ask about that. Otherwise, it's an order from Walgreens, correct? Is there any way to save on this treatment?

I am also doing some reading on the Yahoo board however I trust your experience and intelligence so I thought I would ask you.

Many thanks and know I am cheering for you.
Violet
Quote
Share

DeeinNYC
DeeinNYC

July 19th, 2012, 12:49 pm #2

Hi Violet,

Thank you so much for the well wishes. I wish the same for you. I'm so happy that you were able to see Dr. B and get the testing done. I made the decision to forgo Dq-Alpha/HLA testing because the treatment for this either would be either Neupogen or IVIG, neither of which I could afford if my insurance did not cover it. My Dr gives 25x's the normal intralipid dosage which he says has been as effective for most as IVIG. I also should have mentioned that my Dr was very doubtful that this was my issue. Part of the reason is that he ready had my other immune tests including NK assay. God forbid my donor cycle does not work, I would likely do that testing just for completion and try to figure out how to afford the Neupogen and/or IVIG. SIRM administers intralipids on site for their patients so it's easy to do there. The intralipids themselves are only about $25 at Freedom Pharmacy. The trick is finding someone to infuse them. My insurance thankfully covers this cost. I have heard of people using Walgreens Infusion Center to have a nurse come to them to give the infusion. I think the price depends upon where you are in the country. I also know if people that use a visiting nurse for a couple of hundred dollars to do the infusion. I would ask the ladies on the yahoo board for suggestions on how to save on buying these products.

As far as the single embryo issue, that is what Dr. Sher at SIRM recommends for people with a partial match. The idea is that if you transfer more, a matching embryo might be in the batch and therefore trigger an immune response. I was in a group with a lady that had a partial match and was only successful when she transferred a single embryo. Here is a blog entry of his explaining things:

http://haveababy.com/fertility-informat ... ntroversy/

Now, I'm no great fan of Dr Sher's. I believe that he is wrong when he says that a 100% match can only be treated with surrogacy or donor sperm. Dr. Braverman has had success in these cases with Neupogen and others have also had success in these situations.
Quote
Share

sugar
sugar

July 19th, 2012, 1:07 pm #3

Wow this article is fabulous! Thank you so much for posting the link. As always, wishing you the very best! Sugar
Quote
Share

Violet
Violet

July 19th, 2012, 11:41 pm #4

Hi Violet,

Thank you so much for the well wishes. I wish the same for you. I'm so happy that you were able to see Dr. B and get the testing done. I made the decision to forgo Dq-Alpha/HLA testing because the treatment for this either would be either Neupogen or IVIG, neither of which I could afford if my insurance did not cover it. My Dr gives 25x's the normal intralipid dosage which he says has been as effective for most as IVIG. I also should have mentioned that my Dr was very doubtful that this was my issue. Part of the reason is that he ready had my other immune tests including NK assay. God forbid my donor cycle does not work, I would likely do that testing just for completion and try to figure out how to afford the Neupogen and/or IVIG. SIRM administers intralipids on site for their patients so it's easy to do there. The intralipids themselves are only about $25 at Freedom Pharmacy. The trick is finding someone to infuse them. My insurance thankfully covers this cost. I have heard of people using Walgreens Infusion Center to have a nurse come to them to give the infusion. I think the price depends upon where you are in the country. I also know if people that use a visiting nurse for a couple of hundred dollars to do the infusion. I would ask the ladies on the yahoo board for suggestions on how to save on buying these products.

As far as the single embryo issue, that is what Dr. Sher at SIRM recommends for people with a partial match. The idea is that if you transfer more, a matching embryo might be in the batch and therefore trigger an immune response. I was in a group with a lady that had a partial match and was only successful when she transferred a single embryo. Here is a blog entry of his explaining things:

http://haveababy.com/fertility-informat ... ntroversy/

Now, I'm no great fan of Dr Sher's. I believe that he is wrong when he says that a 100% match can only be treated with surrogacy or donor sperm. Dr. Braverman has had success in these cases with Neupogen and others have also had success in these situations.
I so appreciate your expertise. I somehow left Dr. B's office without the test results and I got overwhelmed with all the #s while I was there so I do not know for sure if we are 100% match or not. I am going to call there tomorrow to find out and then we can figure it out.

Dr. B is wonderful as is his staff. At least I feel like I am in good hands although I am not dying to do all of this treatment.

I contacted insurance and they will cover the neupogen which is helpful. If you were in my shoes, how would you feel about taking it?

Also, did you have any side affects with the intralipids?

How are YOU doing? I really hope this is it for you. I don't know if I told you but a very close friend of mine had success at RBA with the first try and just had her sweet baby recently.

Thanks again.
Violet
Quote
Share

DeeinNYC
DeeinNYC

July 20th, 2012, 2:49 am #5

Violet,

That is so great that your insurance will cover the Neupogen. I have to say, I am FAR from an expert in this area. There is so much I do not know and really rely upon the information and knowledge of others. Since I do not have a known matching issue I have never really studied Neupogen so I have no idea about the pros or the cons. I'm pretty sure though if you do a search of the Yahoo group that you will get tons of thread on it. BTW..set your setting to a Daily Digest or else you will get a million e-mails a day instead of 1 or 2 that have all of the posts from the day. VERY excited that you can get the Neupogen. I know that there have been quite a few successes with it. I hope you are one too!! FX!! You are in good hands with Dr. B from what I understand.

As for intralipids- I've never heard of anyone having side effects. I never have. It's just soybean and egg yolk..they feed this to cancer patients.

AFM- I'm well. Hanging in there. I'm hoping that RBA gets me my take home baby too. Thanks for sharing about your friend. May we all get our take home babies
Quote
Share

DeeinNYC
DeeinNYC

July 20th, 2012, 2:50 am #6

Wow this article is fabulous! Thank you so much for posting the link. As always, wishing you the very best! Sugar
Same to you Sugar FX- n/t
Quote
Share

Violet
Violet

July 21st, 2012, 6:31 pm #7

Violet,

That is so great that your insurance will cover the Neupogen. I have to say, I am FAR from an expert in this area. There is so much I do not know and really rely upon the information and knowledge of others. Since I do not have a known matching issue I have never really studied Neupogen so I have no idea about the pros or the cons. I'm pretty sure though if you do a search of the Yahoo group that you will get tons of thread on it. BTW..set your setting to a Daily Digest or else you will get a million e-mails a day instead of 1 or 2 that have all of the posts from the day. VERY excited that you can get the Neupogen. I know that there have been quite a few successes with it. I hope you are one too!! FX!! You are in good hands with Dr. B from what I understand.

As for intralipids- I've never heard of anyone having side effects. I never have. It's just soybean and egg yolk..they feed this to cancer patients.

AFM- I'm well. Hanging in there. I'm hoping that RBA gets me my take home baby too. Thanks for sharing about your friend. May we all get our take home babies
You are so kind AND intelligent and I appreciate that right now.
I am sending you lots and lots of pg love...let's get pregnant and have that baby already, right?
Thanks again.

The info you gave me was very helpful.
I contacted Walgreens and am getting that going w/ the intralipids...also working on the neupogen as I do have to have it approved for my cheaper insurance option (I have two policies due to ttc.). So, on my way.
Thanks for everything.
Violet
Quote
Share