Wolverine & The X-men- "Hindsight: Parts 1&2" (2008)
Set after a one year gap, wherein Professor X and Jean Grey mysteriously exploded. Or, since it's X-men and comic books, I'm sure they're alive somewhere. Anyways, Mutant Registration is running wild and a militant group called the MRD runs around capturing mutants and even human sympathizers. The X-men have disbanded and dispersed since Xavier's detonation.
When Wolverine saves a little girl from a burning bus, a grateful family gives him a bed for the night. The family is soon captured, spurring Wolvie to re-don his fighting togs and get the band back together. He saves them, with the help of the Beast.
Part 2 introduces the Brotherhood, consisting of Quicksilver, Avalanche, Toad, Blob and Domino (plus her two friends). Seriously, Domino has some mad cleavage going on; almost up to her chin. I don't know much about the character, but I'd say that's one of her mutant powers.
The Bros are out to off Senator Kelly, in yet another interpretation of his anti-mutant political campaign. Wolvie and Beast re-recruit Iceman, Kitty Pryde and Rogue to help. But turns out Rogue was a double-agent, working with the Brotherhood.
I'd say it's probably the best X-men cartoon series I've seen, thus far. I've always said that the X-men and their concepts of mutant paranoia work great in a vaccuum, as this proves. Add in some regular ol' Avenger-type superheroes and the paranoia angle doesn't work. This seems to be digging into the X-world with plenty of cameos, so it may be the first X-men series I watch to its conclusion.