Start bleeding on progesterone

Start bleeding on progesterone

Carol
Carol

August 26th, 2011, 12:29 pm #1

Hi ladies, Can you tell me if this is a problem. I have had 4 failed ivf's. The first 3 i was on 200mg progesterone suppositories twice daily and each time i started spotting and then bleeding 2 to 3 days before beta. This past ivf number 4 i was put on 400mg prog supp twice daily and i still started spotting and bleeding 2 days before beta.

What do you guys think of this. Is this something that you just can't do anything about. Im just worried that im not taking enough. Is the progesterone in oil or the tablets or the cream better. I wonder if i changed would i help. Has anyone ever had this before. Thanks
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AJ
AJ

August 26th, 2011, 1:57 pm #2

I had that happen last cycle. I took 200 units 2/day of the suppositories. When I started spotting a few days before beta Check's nurse doubled my dosage and I still got AF on the day of by beta. I've taken P4 support many previous cycles at the same and even lower dosage and never had that happen. Usually AF wouldn't come until 3-5 days after stopping.

Did you have any monitoring after O to see what your P4 levels were? I wondered if because I'd taken it lots of other cycles my body had just become immune to it, if that's even possible? I'm not doing any monitoring this cycle, just self medicating and trying on our own. I'm a few days away from expected AF so I'm curious to see if I start while taking P4 again.

Maybe the P in oil would be more effective for you? I've never taken it so hopefully someone else can chime in.

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Joined: January 23rd, 2009, 5:02 pm

August 26th, 2011, 2:10 pm #3

Hi ladies, Can you tell me if this is a problem. I have had 4 failed ivf's. The first 3 i was on 200mg progesterone suppositories twice daily and each time i started spotting and then bleeding 2 to 3 days before beta. This past ivf number 4 i was put on 400mg prog supp twice daily and i still started spotting and bleeding 2 days before beta.

What do you guys think of this. Is this something that you just can't do anything about. Im just worried that im not taking enough. Is the progesterone in oil or the tablets or the cream better. I wonder if i changed would i help. Has anyone ever had this before. Thanks
So maybe AF is just ready to come at that point??? If you're not getting a BFP then it doesn't seem too unlikely to start spotting a bit before. If you're just trying to correct a luteal phase defect, i've heard adding vitamin b-6 can help with that too? 100mg. Worth a shot at least, maybe that with the progesterone with lengthen it???



TTC: Since Nov. 2006
Diagnosis: Ovarian Dysfunction & PCOS
28 Years Old
cd3 FSH 16.8
cd10 FSH 13.6
7 Unmonitored Cycles of Clomid
3 Unmonitored Cycles of Letrozole
Positive CCCT
TAB for cysts
1st Cycle of 150iu of Menopur with Timed BDing - 5 mature follies - BFN
TAB for cysts
2nd Cycle of 150iu of Menopur with Timed Intercourse - 4 mature follies in play - BFN
3rd Cycle of 150 iu of Menopur with Timed Intercourse - 2 follies - BFN
1st Cycle of Gonal F - 1 follie & cyst on right - BFN
TAB for a cycle
2nd Cycle of Gonal F = BFP!!!!!
11dpo Beta=27.9
14dpo Beta=120
16dpo Beta=210
18dpo Beta=429
21dpo Beta=1064
5w6d - baby measuring 3mm, h/b 101
6w6d - baby measuring 6mm, h/b 126
7w6d - baby 18mm, h/b 171, measuring ahead at 8w2d! RE noticed enlarged yolk sac so keeping a close eye on that
8w6d - baby 2.52cm with h/b of 174
9w5d - baby 3.22cm with h/b of 180 measuring 10w1d
10w6d - baby 4.34cmcm with h/b of 174 measuring 11w1d
12w u/s showed baby at 11.2cm with h/b of 162 - unfortunately, that evening I suffered a horrible m/c of a chromosomally NORMAL girl.... RIP my angel girl...you were loved....

Gonal F with Timed Intercourse-2WW
First cycle of Gonal F with Timed Intercourse since m/c - BFN
2nd Cycle of Gonal F with Timed Intercourse - BFN
TAB for a month on bcp's
3rd Cycle of Gonal F - BFP
-11dpo beta=14.9
-14dpo beta=45.7
-16dpo beta=140
-18dpo beta=366
u/s at 6w1d showed heart-rate of 114!!!!
u/s at 7w1d showed heart-rate of 141!!!!
u/s at 8w showed heart-rate of 179
u/s at 9w showed 2 SCH's, h/r of 197
u/s at 10w showed h/r of 175
u/s at 11w showed h/r of 180
u/s at 12 w showed h/r of 188
12w2d...m/c'd baby at home, lost too much blood, had to have emergency D&C...severely anemic....baby was a chromosomally normal boy
-developed a blood clot in leg 1 1/2 wks post D&C...saw a hematologist and had testing done and everything came back normal, will still treat me with Lovenex on next pregnancy

-First cycle since m/c....Gonal F, triggered with 8 mature follies, T/I - BFP!
-13dpo beta 106, progesterone 21.4
-15dpo beta 260, progesterone 12.2
-16dpo beta 411, progesterone 16
-20dpo beta 845, progesterone 19 (went in for u/s to rule out ectopic, couldn't see anything yet, but lining was thick)
-22dpo beta 1158, progesterone 18
-24dpo beta 1655, progesterone 20
-5w?? u/s showed 2 sacs...one measuring 4w0d, the other measuring 5w1d....possibly vanishing twin???
-6w u/s showed TWINS! 2 h/r's....121, 119. both measuring 6w1d! SCH 1cm
-At 7w pg, tested positive for lupus anticoagulant, on lovenox to treat it, TSH was 2.55
-7w2d u/s showed 2 babies measuring 7w4d & 7w3d, h/r's 158 & 153! SCH 2cm
-8w1d u/s showed 2 babies measuring 8w3d & 8w2d, h/r's 185 & 179! SCH 3cm
-10w2d u/s showed we lost baby A measuring 9w1d and had no h/r...baby B measured 10w1d with a h/r of 180...praying for Baby B to hang on, SCH gone, started thyroid med
-11w1d u/s showed Baby B measuring right on track, h/r of 174
-12w1d had a red bleeding episode & u/s showed Baby B measuring 1 day ahead and a h/r of 168, bleeding likely caused by Baby A's passing
-13w1d had some red spotting & u/s showed Baby B measuring 2 days behind and h/r of 157
-14w...baby measured 14w3d...and I suffered a horrible, very sudden miscarriage...another angel baby...that makes 4.
Saw Dr Mary Stephenson at U of Chicago for recurrent pregnancy loss....dx with Lupus Anticoagluant and Incompetent Cervix, will be treated with lovenox
5-25-11 - Had a Transabdominal Cerclage placed by Dr Haney at U of Chicago
Gonal F with Timed Intercourse (self medicated/unmonitored) BFN
TTC: Since Nov. 2006
Diagnosis: Ovarian Dysfunction & PCOS
26 Years Old
cd3 FSH 16.8
cd10 FSH 13.6
7 Unmonitored Cycles of Clomid
3 Unmonitored Cycles of Letrozole
Positive CCCT
TAB for cysts
1st Cycle of 150iu of Menopur with Timed BDing - 5 mature follies - BFN
TAB for cysts
2nd Cycle of 150iu of Menopur with Timed Intercourse - 4 mature follies in play - BFN
3rd Cycle of 150 iu of Menopur with Timed Intercourse - 2 follies - BFN
1st Cycle of Gonal F - 1 follie & cyst on right - BFN
TAB for a cycle
2nd Cycle of Gonal F = BFP!!!!!
11dpo Beta=27.9
14dpo Beta=120
16dpo Beta=210
18dpo Beta=429
21dpo Beta=1064
5w6d - baby measuring 3mm, h/b 101
6w6d - baby measuring 6mm, h/b 126
7w6d - baby 18mm, h/b 171, measuring ahead at 8w2d! RE noticed enlarged yolk sac so keeping a close eye on that
8w6d - baby 2.52cm with h/b of 174
9w5d - baby 3.22cm with h/b of 180 measuring 10w1d
10w6d - baby 4.34cmcm with h/b of 174 measuring 11w1d
12w u/s showed baby at 11.2cm with h/b of 162 - unfortunately, that evening I suffered a horrible m/c of a chromosomally NORMAL girl.... RIP my angel girl...you were loved....

First cycle of Gonal F with Timed Intercourse since m/c - BFN
2nd Cycle of Gonal F with Timed Intercourse - BFN
TAB for a month on bcp's
3rd Cycle of Gonal F - BFP
-11dpo beta=14.9
-14dpo beta=45.7
-16dpo beta=140
-18dpo beta=366
u/s at 6w1d showed heart-rate of 114!!!!
u/s at 7w1d showed heart-rate of 141!!!!
u/s at 8w showed heart-rate of 179
u/s at 9w showed 2 SCH's, h/r of 197
u/s at 10w showed h/r of 175
u/s at 11w showed h/r of 180
u/s at 12 w showed h/r of 188
12w2d...m/c'd baby at home, lost too much blood, had to have emergency D&C...severely anemic....baby was a chromosomally normal boy
-developed a blood clot in leg 1 1/2 wks post D&C...saw a hematologist and had testing done and everything came back normal, will still treat me with Lovenex on next pregnancy
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AJ
AJ

August 26th, 2011, 4:55 pm #4

My understanding is that it's the drop in progesterone that triggers the start of AF. And by keeping it artificially elevated AF should hold off until stopping support.
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Joined: January 23rd, 2009, 5:02 pm

August 26th, 2011, 5:31 pm #5

Lets say on a natural cycle with no support, you progesterone level is a 12, around 11dpo it starts to drop, then you might start spotting and then get a bull blown AF. Then on a cycle with support its at a 20. So the support is giving you an 8 point increase. Well, around 11dpo, you bodies natural production of progesterone is still dropping, and that dropping is what's causing the spotting. Even though your progesterone level lmight still be over 12, it's still "dropping" somewhat.

Some women still get full blown AF even while on progesterone support.

Does that make sense?



TTC: Since Nov. 2006
Diagnosis: Ovarian Dysfunction & PCOS
28 Years Old
cd3 FSH 16.8
cd10 FSH 13.6
7 Unmonitored Cycles of Clomid
3 Unmonitored Cycles of Letrozole
Positive CCCT
TAB for cysts
1st Cycle of 150iu of Menopur with Timed BDing - 5 mature follies - BFN
TAB for cysts
2nd Cycle of 150iu of Menopur with Timed Intercourse - 4 mature follies in play - BFN
3rd Cycle of 150 iu of Menopur with Timed Intercourse - 2 follies - BFN
1st Cycle of Gonal F - 1 follie & cyst on right - BFN
TAB for a cycle
2nd Cycle of Gonal F = BFP!!!!!
11dpo Beta=27.9
14dpo Beta=120
16dpo Beta=210
18dpo Beta=429
21dpo Beta=1064
5w6d - baby measuring 3mm, h/b 101
6w6d - baby measuring 6mm, h/b 126
7w6d - baby 18mm, h/b 171, measuring ahead at 8w2d! RE noticed enlarged yolk sac so keeping a close eye on that
8w6d - baby 2.52cm with h/b of 174
9w5d - baby 3.22cm with h/b of 180 measuring 10w1d
10w6d - baby 4.34cmcm with h/b of 174 measuring 11w1d
12w u/s showed baby at 11.2cm with h/b of 162 - unfortunately, that evening I suffered a horrible m/c of a chromosomally NORMAL girl.... RIP my angel girl...you were loved....

Gonal F with Timed Intercourse-2WW
First cycle of Gonal F with Timed Intercourse since m/c - BFN
2nd Cycle of Gonal F with Timed Intercourse - BFN
TAB for a month on bcp's
3rd Cycle of Gonal F - BFP
-11dpo beta=14.9
-14dpo beta=45.7
-16dpo beta=140
-18dpo beta=366
u/s at 6w1d showed heart-rate of 114!!!!
u/s at 7w1d showed heart-rate of 141!!!!
u/s at 8w showed heart-rate of 179
u/s at 9w showed 2 SCH's, h/r of 197
u/s at 10w showed h/r of 175
u/s at 11w showed h/r of 180
u/s at 12 w showed h/r of 188
12w2d...m/c'd baby at home, lost too much blood, had to have emergency D&C...severely anemic....baby was a chromosomally normal boy
-developed a blood clot in leg 1 1/2 wks post D&C...saw a hematologist and had testing done and everything came back normal, will still treat me with Lovenex on next pregnancy

-First cycle since m/c....Gonal F, triggered with 8 mature follies, T/I - BFP!
-13dpo beta 106, progesterone 21.4
-15dpo beta 260, progesterone 12.2
-16dpo beta 411, progesterone 16
-20dpo beta 845, progesterone 19 (went in for u/s to rule out ectopic, couldn't see anything yet, but lining was thick)
-22dpo beta 1158, progesterone 18
-24dpo beta 1655, progesterone 20
-5w?? u/s showed 2 sacs...one measuring 4w0d, the other measuring 5w1d....possibly vanishing twin???
-6w u/s showed TWINS! 2 h/r's....121, 119. both measuring 6w1d! SCH 1cm
-At 7w pg, tested positive for lupus anticoagulant, on lovenox to treat it, TSH was 2.55
-7w2d u/s showed 2 babies measuring 7w4d & 7w3d, h/r's 158 & 153! SCH 2cm
-8w1d u/s showed 2 babies measuring 8w3d & 8w2d, h/r's 185 & 179! SCH 3cm
-10w2d u/s showed we lost baby A measuring 9w1d and had no h/r...baby B measured 10w1d with a h/r of 180...praying for Baby B to hang on, SCH gone, started thyroid med
-11w1d u/s showed Baby B measuring right on track, h/r of 174
-12w1d had a red bleeding episode & u/s showed Baby B measuring 1 day ahead and a h/r of 168, bleeding likely caused by Baby A's passing
-13w1d had some red spotting & u/s showed Baby B measuring 2 days behind and h/r of 157
-14w...baby measured 14w3d...and I suffered a horrible, very sudden miscarriage...another angel baby...that makes 4.
Saw Dr Mary Stephenson at U of Chicago for recurrent pregnancy loss....dx with Lupus Anticoagluant and Incompetent Cervix, will be treated with lovenox
5-25-11 - Had a Transabdominal Cerclage placed by Dr Haney at U of Chicago
Gonal F with Timed Intercourse (self medicated/unmonitored) BFN
TTC: Since Nov. 2006
Diagnosis: Ovarian Dysfunction & PCOS
26 Years Old
cd3 FSH 16.8
cd10 FSH 13.6
7 Unmonitored Cycles of Clomid
3 Unmonitored Cycles of Letrozole
Positive CCCT
TAB for cysts
1st Cycle of 150iu of Menopur with Timed BDing - 5 mature follies - BFN
TAB for cysts
2nd Cycle of 150iu of Menopur with Timed Intercourse - 4 mature follies in play - BFN
3rd Cycle of 150 iu of Menopur with Timed Intercourse - 2 follies - BFN
1st Cycle of Gonal F - 1 follie & cyst on right - BFN
TAB for a cycle
2nd Cycle of Gonal F = BFP!!!!!
11dpo Beta=27.9
14dpo Beta=120
16dpo Beta=210
18dpo Beta=429
21dpo Beta=1064
5w6d - baby measuring 3mm, h/b 101
6w6d - baby measuring 6mm, h/b 126
7w6d - baby 18mm, h/b 171, measuring ahead at 8w2d! RE noticed enlarged yolk sac so keeping a close eye on that
8w6d - baby 2.52cm with h/b of 174
9w5d - baby 3.22cm with h/b of 180 measuring 10w1d
10w6d - baby 4.34cmcm with h/b of 174 measuring 11w1d
12w u/s showed baby at 11.2cm with h/b of 162 - unfortunately, that evening I suffered a horrible m/c of a chromosomally NORMAL girl.... RIP my angel girl...you were loved....

First cycle of Gonal F with Timed Intercourse since m/c - BFN
2nd Cycle of Gonal F with Timed Intercourse - BFN
TAB for a month on bcp's
3rd Cycle of Gonal F - BFP
-11dpo beta=14.9
-14dpo beta=45.7
-16dpo beta=140
-18dpo beta=366
u/s at 6w1d showed heart-rate of 114!!!!
u/s at 7w1d showed heart-rate of 141!!!!
u/s at 8w showed heart-rate of 179
u/s at 9w showed 2 SCH's, h/r of 197
u/s at 10w showed h/r of 175
u/s at 11w showed h/r of 180
u/s at 12 w showed h/r of 188
12w2d...m/c'd baby at home, lost too much blood, had to have emergency D&C...severely anemic....baby was a chromosomally normal boy
-developed a blood clot in leg 1 1/2 wks post D&C...saw a hematologist and had testing done and everything came back normal, will still treat me with Lovenex on next pregnancy
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Anonymous
Anonymous

August 26th, 2011, 8:06 pm #6

sorry to jump in here but I am just trying to learn more thanks
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AJ
AJ

August 28th, 2011, 6:16 pm #7

your body wasn't producing enough progesterone on its own and the pregnancy was otherwise healthy. It would not maintain or improve an unhealthy pregnancy.
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Cathy
Cathy

August 29th, 2011, 6:49 pm #8

because Check actually gives me progesterone to bring on AF. (So now I'm actually a little confused, too) Good luck, though!
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