what to do next?

what to do next?

Dee
Dee

September 12th, 2012, 2:11 am #1

My recent cycle has failed, we used a 29 year old donor who was "proven" according to my clinic because she had 2 children. I took heparin and prednisone, and baby aspirin.

Several things could have gone wrong:

1) I came down w/some sore throat virus 2 weeks before the transfer, and I had to take antibiotics for a couple of days that might have reduced the effectiveness of the hormonal drugs, according to what the pharmacist told me. I was concerned about that, but also concerned about how a virus could affect the IVF outcome.

2) The week before my transfer I had some mild spotting and my lining, which had been going up just fine, started to go down some. The sonographer said it was probably due to something "hormonal". Could the antibiotic have caused this? Was told to increase my estrace dose, and my lining went back up to 11 for the transfer. I still wonder if something went wrong hormonally that affected the cycle.

3) Although donor had children of her own, she was 29 and unproven as far as the IVF process (she was a first time donor).

4) Last December, I had some minor adhesion near my cervix repaired by Dr. March, an expert in the field of diagnosing & repairing adhesions.

I have 3 frozen embryos of "average" quality. I am thinking about intralipids for the next cycle and going back for more acupuncture. I don't know what else to do.
Quote
Share

futurebeauty
futurebeauty

September 12th, 2012, 3:24 am #2

First, sorry for your failed cycle. It sucks to get a BFN after so much time, effort and money. I feel for you and I have been there myself.

Sometimes, clinics prescribe antibiotics as it can help w/ some hidden virus and some ladies have only gotten pregnant when on antibiotics.

I think that intralipids could be something to explore but it is pricy but not outrageous in costs, just another added expense.

I think sometimes we have to remember that DE only works on average 50% of the time. Of course it sounds dreamy compared to our 1-5% chance w/ OE. I really thought that I would fall on the positive side of 50% but it did not work out well for me.

I keep thinking that this is a numbers game and once we have covered all our our pre-existing issues then eventually we will fall on the good side of the numbers and have our take home baby.

Keep on going as you will get there.

Good luck,

FB

Quote
Share

Dee
Dee

September 12th, 2012, 8:12 pm #3

thanks, I want to keep going on, but as I'm getting older, I don't really know how many more years I have left to do this. Every time we fail a cycle, we are emotionally gutted afterward. I don't feel my clinic had the best donor available for me, age 29 with no prior cycles is not really that proven. I've been to the Czech Republic now 3 times, and have nothing but a growing collection of Matroyshka dolls. No baby.
Quote
Share

LizLA
LizLA

September 12th, 2012, 10:25 pm #4

I'm not going to sugar coat...

Get clinic with best results and proven donor...donations resulted in live birth.

There is no guarantee but you will have a better chance.

We also at the time consider Ukraine, especially since I speak the languagh, but I was willing only do it once. Great clinic + young 3 times proven donor= one baby. Also, we had severe male factor.

Good Luck.
Quote
Share

Joined: August 17th, 2011, 2:17 pm

September 13th, 2012, 2:00 am #5

My recent cycle has failed, we used a 29 year old donor who was "proven" according to my clinic because she had 2 children. I took heparin and prednisone, and baby aspirin.

Several things could have gone wrong:

1) I came down w/some sore throat virus 2 weeks before the transfer, and I had to take antibiotics for a couple of days that might have reduced the effectiveness of the hormonal drugs, according to what the pharmacist told me. I was concerned about that, but also concerned about how a virus could affect the IVF outcome.

2) The week before my transfer I had some mild spotting and my lining, which had been going up just fine, started to go down some. The sonographer said it was probably due to something "hormonal". Could the antibiotic have caused this? Was told to increase my estrace dose, and my lining went back up to 11 for the transfer. I still wonder if something went wrong hormonally that affected the cycle.

3) Although donor had children of her own, she was 29 and unproven as far as the IVF process (she was a first time donor).

4) Last December, I had some minor adhesion near my cervix repaired by Dr. March, an expert in the field of diagnosing & repairing adhesions.

I have 3 frozen embryos of "average" quality. I am thinking about intralipids for the next cycle and going back for more acupuncture. I don't know what else to do.
I don't really have suggestions, just wanted to say I'm really sorry to hear your result. Take good care of yourself. Big virtual hug.
Quote
Like
Share

KerriA
KerriA

September 13th, 2012, 2:10 am #6

My recent cycle has failed, we used a 29 year old donor who was "proven" according to my clinic because she had 2 children. I took heparin and prednisone, and baby aspirin.

Several things could have gone wrong:

1) I came down w/some sore throat virus 2 weeks before the transfer, and I had to take antibiotics for a couple of days that might have reduced the effectiveness of the hormonal drugs, according to what the pharmacist told me. I was concerned about that, but also concerned about how a virus could affect the IVF outcome.

2) The week before my transfer I had some mild spotting and my lining, which had been going up just fine, started to go down some. The sonographer said it was probably due to something "hormonal". Could the antibiotic have caused this? Was told to increase my estrace dose, and my lining went back up to 11 for the transfer. I still wonder if something went wrong hormonally that affected the cycle.

3) Although donor had children of her own, she was 29 and unproven as far as the IVF process (she was a first time donor).

4) Last December, I had some minor adhesion near my cervix repaired by Dr. March, an expert in the field of diagnosing & repairing adhesions.

I have 3 frozen embryos of "average" quality. I am thinking about intralipids for the next cycle and going back for more acupuncture. I don't know what else to do.
Hi Dee,
I am so sorry for your BFN. They can be so soul-crushing I know. I've had 7 good to excellent blasts total transferred into my uterus of death, and none of them have stuck around. Like you, I am trying to figure out what to try different and even if I should pursue a different path. I had lots of great input when I posed this question down below. Daisy, in particular, gave a great list. Here's the link:http://www.network54.com/Forum/57451/me ... -c+ment%29

I do agree with FB - that sometimes it does seem to be a numbers game, and I think top clinic/proven donor is the best way to go.

thinking of you and wishing you lots of luck!
kerri
Quote
Share

Dee
Dee

September 13th, 2012, 2:48 am #7

thanks for that list. I have actually had some of that testing done recently, like the thyroid test and hysteroscopy. Also was tested for ureaplasma & mycoplasma (had this test done 3 times this year and it was negative each time). I have not been tested for the NK though. I think we are dealing with faulty sperm.
Quote
Share

Zoya2
Zoya2

September 13th, 2012, 2:10 pm #8

My recent cycle has failed, we used a 29 year old donor who was "proven" according to my clinic because she had 2 children. I took heparin and prednisone, and baby aspirin.

Several things could have gone wrong:

1) I came down w/some sore throat virus 2 weeks before the transfer, and I had to take antibiotics for a couple of days that might have reduced the effectiveness of the hormonal drugs, according to what the pharmacist told me. I was concerned about that, but also concerned about how a virus could affect the IVF outcome.

2) The week before my transfer I had some mild spotting and my lining, which had been going up just fine, started to go down some. The sonographer said it was probably due to something "hormonal". Could the antibiotic have caused this? Was told to increase my estrace dose, and my lining went back up to 11 for the transfer. I still wonder if something went wrong hormonally that affected the cycle.

3) Although donor had children of her own, she was 29 and unproven as far as the IVF process (she was a first time donor).

4) Last December, I had some minor adhesion near my cervix repaired by Dr. March, an expert in the field of diagnosing & repairing adhesions.

I have 3 frozen embryos of "average" quality. I am thinking about intralipids for the next cycle and going back for more acupuncture. I don't know what else to do.
I'm so sorry about your BFN, and I'm so sorry you've gone through so much.

As far as what else you could do, I would echo what LizLA said with a caveat. I agree that going with a clinic with a super high success rate plus a proven donor is a really good option. I did just that, and for me it was like throwing everything I possibly could at the problem. However, a big caveat is that the super high success rate clinics are very expensive for one cycle. It's great if you have frozens from your one fresh cycle - giving you the option of frozen cycles for around $5K - but it's never something you can count on no matter where you go.

Have you considered Shady Grove? If I had around $30K (plus travel cost, if applicable) to spend but wanted to have the feeling of having insurance, I would do SG's 3:1 shared risk program. The money back guarantee is pretty great. If I had around $30K (plus travel) to spend on one cycle throwing everything I had at the problem to give me my best shot in one cycle, I would go with a clinic with a high success rate.

One plus of SG over the 70-80% live birth/cycle clinics is that you can still be accepted into their shared risk program if you have previous failed DE cycles. My 70-80% success rate clinic has a guarantee program, but it's not nearly as financially attractive as SG's, and they won't offer you the money back guarantee if you have previous failed DE cycles.

Good luck, Dee!
Quote
Share

DeeinNYC
DeeinNYC

September 13th, 2012, 2:36 pm #9

My recent cycle has failed, we used a 29 year old donor who was "proven" according to my clinic because she had 2 children. I took heparin and prednisone, and baby aspirin.

Several things could have gone wrong:

1) I came down w/some sore throat virus 2 weeks before the transfer, and I had to take antibiotics for a couple of days that might have reduced the effectiveness of the hormonal drugs, according to what the pharmacist told me. I was concerned about that, but also concerned about how a virus could affect the IVF outcome.

2) The week before my transfer I had some mild spotting and my lining, which had been going up just fine, started to go down some. The sonographer said it was probably due to something "hormonal". Could the antibiotic have caused this? Was told to increase my estrace dose, and my lining went back up to 11 for the transfer. I still wonder if something went wrong hormonally that affected the cycle.

3) Although donor had children of her own, she was 29 and unproven as far as the IVF process (she was a first time donor).

4) Last December, I had some minor adhesion near my cervix repaired by Dr. March, an expert in the field of diagnosing & repairing adhesions.

I have 3 frozen embryos of "average" quality. I am thinking about intralipids for the next cycle and going back for more acupuncture. I don't know what else to do.
I am sorry that this cycle did not work out. I can only add to what everyone else is saying. I would only use a proven donor that has actually cycled before and who has a good track record. I would also get a full immune work-up including a NK Assay and DQ-Alpha and HLA testing in addition to a full thrombophilia blood clotting panel if you have not done so already. I'm curious as to why you think that this is a sperm issue and what sperm issue do you think is at work.
Quote
Share

Dee
Dee

September 13th, 2012, 5:12 pm #10

I'm so sorry about your BFN, and I'm so sorry you've gone through so much.

As far as what else you could do, I would echo what LizLA said with a caveat. I agree that going with a clinic with a super high success rate plus a proven donor is a really good option. I did just that, and for me it was like throwing everything I possibly could at the problem. However, a big caveat is that the super high success rate clinics are very expensive for one cycle. It's great if you have frozens from your one fresh cycle - giving you the option of frozen cycles for around $5K - but it's never something you can count on no matter where you go.

Have you considered Shady Grove? If I had around $30K (plus travel cost, if applicable) to spend but wanted to have the feeling of having insurance, I would do SG's 3:1 shared risk program. The money back guarantee is pretty great. If I had around $30K (plus travel) to spend on one cycle throwing everything I had at the problem to give me my best shot in one cycle, I would go with a clinic with a high success rate.

One plus of SG over the 70-80% live birth/cycle clinics is that you can still be accepted into their shared risk program if you have previous failed DE cycles. My 70-80% success rate clinic has a guarantee program, but it's not nearly as financially attractive as SG's, and they won't offer you the money back guarantee if you have previous failed DE cycles.

Good luck, Dee!
Thanks. I would consider Shady Grove if I had an extra 30K right now. I would also consider doing a split cycle that costs less (where you share eggs with another couple).

My Czech clinic is offering us one remaining free cycle with DE, since the first two did not work out. If the last cycle does not work, then I can't see a reason to continue working with this clinic anyway.
Quote
Share