Rant, also opinions of "bad batch" of eggs

Rant, also opinions of "bad batch" of eggs

jennifer
jennifer

November 15th, 2010, 8:18 pm #1

Hello ladies. I am a bitter woman today and needing to vent..but i also have a questions. I have had two pregnancies with donor eggs and now two miscarriages. In the first miscarriage the sac never formed properly, and in the current one the baby's heart just stopped beating. My RE wants me to do a d&c to test for chromosomal problems. Is there a chance my whole batch of eggs is bad? We only have three left, but I am wondering if it's even worth it to go ahead.
Has anyone experienced this before, and should I let the agency know? My RE said it would be a crazy coincidence, or her eggs could be bad.
any thoughts?
thanks-
jennifer
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Joined: July 29th, 2009, 6:13 pm

November 15th, 2010, 9:13 pm #2

I am sure you will hear from others -- many of us have fallen on the wrong side of the odds a number of times. Nationally, the DE live birth rate is not much above 50% so that is easy to do. A "bad batch" of eggs is not unheard of. I had 2 of them. I am now 38 wks pregnant from my 3rd donor. I think both my initial donors gave me too many bad eggs as DH is fine and my uterus is fine.

To me, REs tend to gloss over the fact that young donors do not have perfect eggs 100% of the time. I am actually a bit amazed that your RE is actually admitting something close to that. I am convinced that in one of my bad cycles, my donor was oversuppressed which meant she did not produce as many eggs as in the past and then those she produced were low quality. In my other bad cycle, I got pregnant and then had a missed m/c when the baby's heart was not beating at the 9 wk u/s. We did a D&C and the baby had Trisomy 15 which is not very compatible with life. We had no other embies left so we did not test anything else. My RE called an "unhappy accident".
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movingforwardhappily!
movingforwardhappily!

November 15th, 2010, 9:17 pm #3

Hello ladies. I am a bitter woman today and needing to vent..but i also have a questions. I have had two pregnancies with donor eggs and now two miscarriages. In the first miscarriage the sac never formed properly, and in the current one the baby's heart just stopped beating. My RE wants me to do a d&c to test for chromosomal problems. Is there a chance my whole batch of eggs is bad? We only have three left, but I am wondering if it's even worth it to go ahead.
Has anyone experienced this before, and should I let the agency know? My RE said it would be a crazy coincidence, or her eggs could be bad.
any thoughts?
thanks-
jennifer
But I am so sorry you have to go through this. I hope you get the answers you need.Hugs MFH
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jennifer
jennifer

November 15th, 2010, 9:27 pm #4

I am sure you will hear from others -- many of us have fallen on the wrong side of the odds a number of times. Nationally, the DE live birth rate is not much above 50% so that is easy to do. A "bad batch" of eggs is not unheard of. I had 2 of them. I am now 38 wks pregnant from my 3rd donor. I think both my initial donors gave me too many bad eggs as DH is fine and my uterus is fine.

To me, REs tend to gloss over the fact that young donors do not have perfect eggs 100% of the time. I am actually a bit amazed that your RE is actually admitting something close to that. I am convinced that in one of my bad cycles, my donor was oversuppressed which meant she did not produce as many eggs as in the past and then those she produced were low quality. In my other bad cycle, I got pregnant and then had a missed m/c when the baby's heart was not beating at the 9 wk u/s. We did a D&C and the baby had Trisomy 15 which is not very compatible with life. We had no other embies left so we did not test anything else. My RE called an "unhappy accident".
that's such great news to hear. I'm so sorry it was a long road for you. You know, I was always convinced that the donor route was paved with gold---that it was so easy once i made that decision. I can't believe it's not working out for me either! WE will have my husband's sperm tested, but the RE said there is only a 1% chance it's the sperm. damn those eggs!!!!!

It's good to know it's happened to others, I think we will try find see if we can find the money for a second donor. I was so sure we were over that, but what can you do?
thank for the reply!
jennifer
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jennifer
jennifer

November 15th, 2010, 9:28 pm #5

But I am so sorry you have to go through this. I hope you get the answers you need.Hugs MFH
it really sucks, but i am trying to move forward!
thanks for reaching out to me!
jennifer
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Joined: July 29th, 2009, 6:13 pm

November 15th, 2010, 10:20 pm #6

that's such great news to hear. I'm so sorry it was a long road for you. You know, I was always convinced that the donor route was paved with gold---that it was so easy once i made that decision. I can't believe it's not working out for me either! WE will have my husband's sperm tested, but the RE said there is only a 1% chance it's the sperm. damn those eggs!!!!!

It's good to know it's happened to others, I think we will try find see if we can find the money for a second donor. I was so sure we were over that, but what can you do?
thank for the reply!
jennifer
Thank you. I still don't believe it some days.

I am not sure if you have seen any "green girls" referenced on this board but there is, unfortunately, a whole subset of DE ladies who have had to try multiple donors and cycles to get their take-home babies. Unfortuntately some of them are still trying. A number of ladies post over there (still TTC with DE) but also post here on the yellow and some of them may chime in. A couple of them, who had big egg producer donors, have actually done extensive testing of their embies just so that they do not keep doing FET after FET with little chance of success. One of them is on vacation and the other posts a bit more intermittently these days but she may see your questions.

I don't want to be a downer here since there are a number of ladies who get preggo right off the bat with DE and then get 1-2 siblings to boot from the same "batch". But there a number of others for whom that does not happen.

One other thing you might look into is a shared risk option -- a number of clinics offer this and it provides some financial protection in the event you don't get pregnant. After my first 2 fresh cycles I switched to Shady Grove in the DC area where I did shared risk.
Last edited by JuJules on November 15th, 2010, 10:22 pm, edited 1 time in total.
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JPE78
JPE78

November 15th, 2010, 10:25 pm #7

it really sucks, but i am trying to move forward!
thanks for reaching out to me!
jennifer
I had 2 chemical pregnancies with my last donor. My RE said the embryos must have stopped growing because there wasn't a uterine issue. I switched to a new clinic and am currently awaiting my transfer with a new donor so we'll see if I have better luck this time. I agree, you can still have issues with healthy young donors.
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Joined: July 3rd, 2004, 10:12 pm

November 15th, 2010, 10:27 pm #8

Hello ladies. I am a bitter woman today and needing to vent..but i also have a questions. I have had two pregnancies with donor eggs and now two miscarriages. In the first miscarriage the sac never formed properly, and in the current one the baby's heart just stopped beating. My RE wants me to do a d&c to test for chromosomal problems. Is there a chance my whole batch of eggs is bad? We only have three left, but I am wondering if it's even worth it to go ahead.
Has anyone experienced this before, and should I let the agency know? My RE said it would be a crazy coincidence, or her eggs could be bad.
any thoughts?
thanks-
jennifer
experience.

I would just like to say that, while it is possible that you were unlucky with abnormal embryos both times, there is also the possibility that there is something possibly going wrong with either DH's sperm or your system.

Forgive me if you have already done this, but before trying again, I would try and have as many recurrent miscarriage/implantation failure tests as possible to eliminate other common reasons for failure.

These would include:-

DH karyotype plus sperm dna fragmentation testing
Thyroid testing for you - TSH needs to be between 1 and 2 ideally for conception. Include T3, T4 and antithyroid antibodies.
Clotting panel (including MTHFR)
Antinuclear antibodies and other autoimmune issues
Uterine tests (e.g. polyps, fibroids etc)
Infection for you and DH (chlamydia, ureaplasma and mycoplasma)

There are further level 2 immune tests e.g. NK Cells/TNfa etc. which you might also like to persue with a specialist reproductive immunologist. The ones above can all be done via a GP and or your clinic possibly. I would discuss the implications of this with your RE.

Again, sorry if this is covering any old ground for you, but I was found to have several issues which caused multiple m/cs with my own eggs and DE. These were treatable with medication.

Cytogenetic testing on the pregnancy may give you some useful information about whether the pregnancy was abnormal or whether it may have been another issue. And this may help with your decision.

Daisy
x
Last edited by loochieuk on November 15th, 2010, 10:31 pm, edited 1 time in total.
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macphee
macphee

November 16th, 2010, 12:10 am #9

Hello ladies. I am a bitter woman today and needing to vent..but i also have a questions. I have had two pregnancies with donor eggs and now two miscarriages. In the first miscarriage the sac never formed properly, and in the current one the baby's heart just stopped beating. My RE wants me to do a d&c to test for chromosomal problems. Is there a chance my whole batch of eggs is bad? We only have three left, but I am wondering if it's even worth it to go ahead.
Has anyone experienced this before, and should I let the agency know? My RE said it would be a crazy coincidence, or her eggs could be bad.
any thoughts?
thanks-
jennifer
The donor had 24 mature egges, all fertilized w/ ICSI. The RE at the transfer said there was such a high likelihood of twins was I sure I wanted to transfer two. She also said I'd have all the embryos needed to complete my family. Long story short, 4 transfers (mc @6 weeks, mc just before 6 weeks, chemical and BFN). I'm waiting for the cycle review to hear what the REs think. They've consistently said the embryos look great. I've had a boatload of testing that doesn't indicate a cause, partner has some sperm issues, hence use of ICSI, but they believe he's ok and RE's day 3, two at a time transfer approach prolonged the agony. What galls me more is the agency using my MC & # of eggs as selling point for donor who is still listed despite not achieving a pregnancy for the 2nd intended parents. REs talk about DE w/ glowing 75% success rates after a fresh and two frozen transfers it's hard not to get sucked in. We are looking to find another donor and hope that it will work b/c this is the last one we can afford. The inability to get a definite cause is more than frustrating and makes one wonder if another try is throwing good money after bad. I'm sorry to be a downer but hope my story helps to manage expectations. This can be a tough roller coaster ride.
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Joined: October 9th, 2008, 2:53 am

November 16th, 2010, 12:29 am #10

Hello ladies. I am a bitter woman today and needing to vent..but i also have a questions. I have had two pregnancies with donor eggs and now two miscarriages. In the first miscarriage the sac never formed properly, and in the current one the baby's heart just stopped beating. My RE wants me to do a d&c to test for chromosomal problems. Is there a chance my whole batch of eggs is bad? We only have three left, but I am wondering if it's even worth it to go ahead.
Has anyone experienced this before, and should I let the agency know? My RE said it would be a crazy coincidence, or her eggs could be bad.
any thoughts?
thanks-
jennifer
Hi Jennifer,
I do believe that an entire batch of eggs can be 'bad'. My first donor was over stimulated, nobody told me. I did four different cycles - the last of which resulted in the remaining three embyros dying on the day of transfer.
It was then that I found out the donor had been hyperstimmed so all the embyros from the get go were flawed and I wasted a total of two and a half years on that donor. I cant tell you how angry I was.
I am sure Wilson will chime in here at some point.
I dont know what kind of testing you could have done but get your RE to look into it, TH.
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