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Pharmaceutical compositions that are useful in the methods of the invention may be administered systemically in oral solid formulations, ophthalmic, suppository, aerosol, topical or other similar formulations.
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The instant invention may be used to treat all possible combination and permutations of conditions, states and disease symptoms as provided herein for protection, including by way of non- limiting exemplification, those shown in Table 3, below.
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The method comprises administering to a mammal in need thereof an effective amount of a composition comprising a 5-HT4 receptor ligand, wherein the ligand has a Ki value of less than about 1 μM for binding thereof to said 5-HT4 receptor, and further wherein the ligand is capable of modulating activity of an immune cell.
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In one embodiment, the delivery methods and devices described herein may be used in gene-based therapy applications.
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In this manner, the proximal end portion 711 can be physically and fluidically coupled to any suitable medical device, as described above.
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In alternative embodiments, the therapeutic combination(s) of drugs are formulated for administration intravenously, topically, orally, by inhalation, by infusion, by injection, by inhalation, intraperitoneally, intramuscularly, subcutaneously, intra- aurally, for intra-articular administration, for intra-mammary administration, for topical administration or for absorption through epithelial or mucocutaneous linings; or are formulated for administration using any route or combination of routes of administration.
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Exemplary NCCN therapies that can be used to practice this invention can be categorized under "Treatment by Site" include treatments for: 1) Acute Myeloid Leukemia; 2) Bladder Cancer (incl.
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NCCN therapies), and are exemplified by NCCN therapies in the category of A) NCCN "Treatment Of Cancer By Site" and in the category of B) NCCN "Supportive Care".
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The distal end of the microneedle includes a bevel that corresponds, at least partially, to a target location within the eye.
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Effector functions can also be assessed qualitatively or quantitatively both in vitro and in vivo with the aid of known functional assays.
The microneedle 310 can be included in, for example, the medicament delivery device 200 described above with reference to FIG.
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In alternative aspects, these embodiments are used to package drugs where product tampering is a consideration, such as the public sale of pharmaceuticals, including the therapeutic combinations of this invention.
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The delivery of substances to the eye and the inhibition of the growth of retinoblastoma cells using the microneedles described herein compared to standard needles was evaluated.
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Although the descriptions of pharmaceutical compositions provided herein are principally directed to pharmaceutical compositions that are suitable for ethical administration to humans, it will be understood by the skilled artisan that such compositions are generally suitable for administration to animals of all sorts.
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FIELD OF THE INVENTION This invention relates generally to medicine and pharmaceutical formulations.
In alternative embodiments the invention provides a kit or kits for the treatment, amelioration or prevention of a mucositis, a cancer or any dysfunctional cell condition, a side effect from the treatment of a cancer or dysfunctional cell condition, a chronic Systemic Inflammatory Response State (SIRS) or a maladaptive nutritional state in a patient population, the kit comprising a therapeutic combination of the invention, or the pharmaceutical composition or formulation of the invention, and instructions for use of the therapeutic combination or pharmaceutical composition.
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Can be self-administered in less than 5 minutes and evaluates eight categories of daily functioning: dressing, arising, eating, walking, hygiene, reach, grip, activities.
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Between January 2004 and October 2012, 8 individuals taking CHLORHEXIDINE GLUCONATE reported PANCREATIC NEUROENDOCRINE TUMOUR METASTATIC to the FDA.
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In some embodiments, the outer diameter di of the microneedle 810 is 30 gauge, 32 gauge, 34 gauge or 36 gauge.
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The microneedle can be disposed within a needle cap prior to use.
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In another embodiment, the system 1360 can further include a flowmeter or other means to monitor flow through the microneedle 1310 and to coordinate use of the pumps and valves.
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For example, in some embodiments, a retinoblastoma is extracted from an eye and less retinoblastoma seeds accumulate in the needle tract in comparison to extraction of retinoblastoma using a 30 gauge needle.
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In alternative embodiments of a blister pack or a plurality of blister packettes, a blister package, a lidded blister or a blister card or packet, a clamshell, a tray or a shrink wrap of the invention, or a paper, plastic or cellophane package or a plurality of packettes of the invention, the drug combination is formulated, packaged or designed for drug regimen compliance of a cancer patient population having mild or severe mental retardation, slow cognition, dementia, senility, Alzheimer's disease, traumatic brain injury, chemical brain damage, mental diseases (e.
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Still another particularly preferred hydrophobic active, which may be used in accordance with the present invention, is dithranol.
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